ABSTRACT
To evaluate abnormal lipid metabolism as a risk factor of eclampsia in pregnant women. This cross sectional study was conducted in three tertiary care hospitals of Peshawar. Serum total cholesterol [TC], high density lipoprotein cholesterol [HDL-C], low density lipoprotein cholesterol [LDL-C], very low density lipoprotein cholesterol [VLDL-C], triglyceride [TG], apolipoprotein A1 [APO-A1], APO-B100, lipoprotein-a [Lpa] were measured in 110 women with eclampsia and compared with 90 healthy pregnant women. Mean lipid levels in cases and controls were compared using student's t test. Mean systolic/diastolic blood pressure, TC, TG, VLDL-C and Lpa levels were significantly higher [p < 0.001] in patients compared to control women. Similarly TC: HDL-C, LDL-C: HDL-C and TG: HDL-C ratio in the patients group were significantly higher [p < 0.001] and HDL-C: VLDL-C ratio was significantly lower [p < 0.001] in the patients as compared to control group. Undesirable cholesterol were noted in 35.8% patients, HDL-C in 50.5%, borderline high concentration of LDL-C in 23.6%, high triglycerides levels in 73.2%, undesirable cholesterol ratio in 52.3% and undesirable LDL-C ratio were noted in 82.1% patients of eclampsia. Serum lipids were found significantly higher thus early assessment may be helpful in prevention of complications in the eclampsia patients